معرفی
David Munn is a Professor at the Medical College of Georgia at Augusta University, with joint appointments in the Department of Pediatrics: Hematology/Oncology, Georgia Cancer Center, Pathology, Medicine, Biochemistry and Molecular Biology, and Cellular Biology and Anatomy. He serves as Co-Director of the Pediatric Immunotherapy Program, leading translational research in tumor immunology and immune suppression.
His research focuses on the molecular mechanisms tumors use to evade immune detection, particularly through the IDO and BTK pathways. Key areas include:
- Regulation of regulatory T cells (Tregs) and tolerogenic dendritic cells in the tumor microenvironment
- Development of small-molecule inhibitors targeting immune checkpoints
- Design and immune monitoring of clinical trials combining IDO inhibitors with chemotherapy and radiation
- First-in-children trials for pediatric brain tumors
His recent publications highlight work on BTK-IDO-mTOR axis inhibition, IDO inhibitor trials in melanoma, and mechanisms of immunosuppression in glioblastoma and aging. His research is supported by the National Institutes of Health and charitable foundations.
Scientific contributions and service include:
- Published in high-impact journals including Science Immunology, Nature Immunology, and Immunity
- Chair, GCC Internal Promotion and Tenure Advisory Committee (2020)
- Chair, GCC PRMC (Protocol Review and Monitoring Committee) (2020)
- Member, GCC Director Search Committee (2019)
- Reviewer for professional journals (since 2015)
Dr. Munn mentors a research team including postdoctoral fellows and research associates, and leads the Munn Lab at the M. Bert Storey Research Building. His work bridges fundamental immunology and clinical application, advancing novel immunotherapies for both adult and pediatric cancers.
