David M Tishler

David M Tishler is a part-time Clinical Professor of Pediatrics at the University of Southern California, affiliated with the Department of Pediatrics. His clinical and research work focuses on pediatric neuro-oncology and neurological complications arising from childhood cancer treatments.

His research spans Pediatrics, Neurology, Oncology, Psychiatry, Pharmacology, and Genetics, with emphasis on drug resistance mechanisms in pediatric brain tumors, genetic mutations in central nervous system malignancies, and long-term neuropsychiatric outcomes in cancer survivors. Key investigations include MDR1 gene expression, p53 mutation analysis, and multidrug resistance pathways in primitive neuroectodermal tumors (PNET).

Analysis of his 1992-2007 publications reveals sustained focus on pediatric CNS tumors, particularly PNET. His work bridges molecular biology and clinical neurology, examining chemotherapy resistance mechanisms, genetic profiles of brain tumors, and psychiatric sequelae in survivors. This integrated approach addresses critical challenges in treatment efficacy and quality-of-life outcomes for pediatric cancer patients.