معرفی
David H. Mathews, M.D., Ph.D., is a Professor and the Lynne E. Maquat Distinguished Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry. His research focuses on RNA structure and function, including computational modeling of RNA folding, riboswitch mechanisms, and the impact of RNA modifications on cellular processes.
Education:
- MD: University of Rochester School of Medicine and Dentistry, 2003
- PhD: University of Rochester, Chemistry, 2002
- BS: University of Rochester, Physics, 1994
Research Interests: Dr. Mathews investigates RNA's role in cellular processes, particularly RNA structure prediction, computational tools for molecular biology, and the functional implications of RNA modifications such as 3-methylcytosine. His work integrates experimental and computational approaches to understand how RNA structures regulate gene expression and translation.
Publications: His recent work highlights advancements in RNA design algorithms, structural analysis of riboswitches, and the development of tools like RNAstructure for secondary structure prediction. Key themes include improving force fields for RNA simulations and exploring the dynamics of RNA-protein interactions.
Awards:
- Lynne E. Maquat Distinguished Professorship
Labs/Teams: Dr. Mathews leads a research group focused on computational and structural RNA biology, collaborating on projects ranging from viral RNA structure analysis to synthetic RNA design.
