معرفی
David Evans is a Professor and the UW Medical Foundation (UWMF) Professor of Pathology & Laboratory Medicine at the University of Wisconsin–Madison, School of Medicine and Public Health. His research is conducted at the AIDS Vaccine Research Laboratory located in the Microbial Sciences Building. He is a leading expert in host-pathogen interactions, particularly in the context of HIV and SIV.
Research Interests: His work focuses on understanding how lentiviruses interact with the host immune system, with major emphasis on:
- Mechanisms of tetherin/BST-2 antagonism by viral proteins (Nef, Vpu, Env)
- Natural killer (NK) cell regulation through KIR and MHC class I interactions
- Antibody-dependent cellular cytotoxicity (ADCC) as a protective immune mechanism
- Development of functional antibody assays for vaccine evaluation
Publication Trends: His recent publications (2022–2025) highlight sustained research on viral immune evasion, ADCC, and novel antibody-based interventions to control viral rebound after antiretroviral therapy (ART) interruption. His work increasingly involves translational approaches such as AAV-mediated antibody delivery and dual immunotherapy strategies in non-human primate models.
Scientific Awards:
- No specific awards are mentioned in the provided text.
Advising and Grants: Dr. Evans has mentored numerous students and postdoctoral researchers, many of whom are co-authors on his publications. His research is supported by significant funding, likely from NIH or similar agencies, given the scale and duration of his studies, though specific grants are not listed. He has contributed to major collaborative efforts such as the RV144 vaccine trial immune correlates analysis.
Laboratories and Teams: He leads the AIDS Vaccine Research Laboratory at UW–Madison, which employs a multidisciplinary team of virologists, immunologists, and molecular biologists. His lab collaborates extensively with other institutions and is deeply integrated into the broader HIV/SIV research community using rhesus macaque models.
