David B Shackelford

David B Shackelford is a Professor in the School of Medicine at the University of California Los Angeles, specializing in Cancer Metabolism and Mitochondrial Biology. His research focuses on the metabolic vulnerabilities of lung and other cancers, particularly in tumors with LKB1 mutations and KRAS dependencies.

• Key Research Themes: Mitochondrial heterogeneity, metabolic reprogramming, and drug targeting in oncology.
• Grants: NIH R01CA208642 (2016–2021) for imaging mitochondrial networks in LKB1 mutant lung cancer.

His recent work explores sphosphorylation pathways, amino acid metabolism, and mitochondrial membrane potential imaging. Publications highlight collaborations with multidisciplinary teams and translational studies in liposarcoma, glioblastoma, and fibrolamellar carcinoma.

• Trends in Publications: 2024 studies emphasize PGC-1α in neuroendocrine cancer, ASCL1 subtypes, and dsRNA trafficking.
• Clinical Relevance: Trials on metabolic drugs like phenformin and mTOR inhibitors for NSCLC and glioma.