David A Guertin

David A Guertin is a Professor at UMass Chan Medical School, affiliated with the T.H. Chan School of Medicine and the Program in Molecular Medicine. His research focuses on nutrient sensing, metabolic regulation, and the mTOR pathway, with significant implications in cancer, diabetes, and obesity.

Education:

• BS in Science, Saint Michael's College
• PhD in Philosophy, University of Massachusetts Medical School
• Postdoc, Whitehead Institute for Biomedical Research (2009)

Guertin's work explores the interplay between nutrient sensing signaling mechanisms and metabolism, particularly through the mTOR pathway. He has contributed to understanding mTOR complex 2 (mTORC2), brown adipose tissue development, and metabolic homeostasis. His research also links altered nutrient sensing to diseases like cancer, diabetes, and tuberculosis.

Recent publications highlight his team's analysis of metabolic dependencies in brown adipocytes, mTORC2-AKT signaling, and pathways like PTHrP in pancreatic cancer cachexia. Articles span journals such as Nature Metabolism, Genes & Development, and Cell Reports, emphasizing metabolism, cell biology, and genetic regulation.

Scientific Awards:

• Damon Runyon Cancer Research Fellowship
• Leukemia & Lymphoma Society Special Fellow
• NIH/NCI Pathway to Independence Award
• PEW Scholar Award
• Charles Hood Foundation Child Health Research Award
• Leukemia & Lymphoma Research Scholar

Guertin's lab offers postdoctoral positions and is part of interdisciplinary programs like the MD/PhD Program and the Diabetes and Endocrinology Research Center. He mentors students and trains researchers in molecular medicine and cancer metabolism.