Darrel W. Stafford

Darrel W. Stafford is a Professor in the Department of Biology at the University of North Carolina at Chapel Hill, affiliated with the College of Arts & Sciences. His research focuses on molecular biology, protein interactions, and blood coagulation pathways. He leads a lab investigating nucleosome phasing, histone interactions, and enzymatic mechanisms in coagulation proteins.

Notable achievements include pioneering early gene isolation techniques in sea urchins and recent advancements in cloning the γ-glutamyl carboxylase enzyme. Research methodologies include molecular modeling, in vitro mutagenesis, and protein purification.

Current studies emphasize understanding coagulation pathways through protein interaction analysis and enzyme characterization. His work bridges basic molecular mechanisms with clinical implications in blood disorder research.