معرفی
Dr. Darja Ivannikov is a Researcher at the Institute of Functional Interfaces (IFG) within the Karlsruhe Institute of Technology (KIT), where she leads innovative work in tissue engineering and microfluidic bioreactor development. Her research focuses on establishing vascularized 3D organotypic cell cultures as ethical alternatives to animal testing.
Her primary research explores microvascular system modeling using the proprietary µ3DVasc bioreactor platform. This microfluidic device features a porous microcapillary for endothelial cell culture surrounded by a 3D tissue chamber, enabling recreation of human physiological interfaces. Key research areas include:
- Development of liver tissue models with integrated bile ducts
- Transendothelial drug transport analysis
- Tumor microenvironment simulation
- Stem cell niche engineering
- In vitro toxicology screening systems
Her work bridges tissue engineering, microfluidics, and regenerative medicine, with significant implications for pharmaceutical development and reduction of animal testing. Current projects emphasize creating perfused 3D tissue models that accurately replicate human vascular interfaces for drug efficacy and toxicity studies.
