Darius Balciunas

Darius Balciunas is a Professor in the Department of Biology at Temple University's College of Science and Technology. His research focuses on the genetic mechanisms of tissue regeneration using zebrafish as a model organism, particularly cardiac regeneration and developmental biology.

• University: Temple University
• School: College of Science and Technology
• Department: Department of Biology
• Email: darius@temple.edu

Dr. Balciunas investigates how genetic programs governing regeneration in zebrafish can inform human biology. His work employs CRISPR/Cas9, transposable elements, and site-specific recombinases to study gene function during regeneration. Key projects include conditional mutagenesis of tbx5a, tbx20, and tcf21 genes and the development of tools like GeneWeld and EpicTope for precise genetic modifications.

Recent publications highlight advancements in zebrafish transgenics, conditional mutagenesis strategies, and molecular mechanisms underlying cardiac regeneration. His lab's work bridges developmental biology and regenerative medicine, focusing on evolutionarily conserved pathways.

The Balciunas Lab develops and refines genetic tools to manipulate zebrafish genes, enabling studies of regeneration in adult organisms. Notable methods include epitope tagging, loxP site integration, and oligonucleotide-mediated repair techniques.

For more information, visit the lab website at http://www.balciunaslab.com/.