معرفی
Daniela Nasteska is a Diabetes UK RD Lawrence Fellow at the University of Oxford’s Radcliffe Department of Medicine, affiliated with Wolfson College. Her research focuses on protein synthesis dynamics in pancreatic islets, particularly in the context of Type 2 diabetes. She leads the Nasteska Group, investigating mechanisms governing beta cell function and survival.
Background: Trained as a medical doctor in Macedonia, she earned her PhD in Japan at Kyoto University’s Department of Diabetes, Endocrinology and Nutrition, studying incretin pathophysiology. Post-PhD, she worked at Université Libre de Bruxelles and the University of Birmingham, expanding her research into beta cell heterogeneity and metabolic stress responses.
Research Interests: Her work spans protein turnover in islets, beta cell plasticity, and molecular mechanisms underlying diabetes pathogenesis. Key projects include longitudinal tracking of protein synthesis and identifying druggable pathways to enhance beta cell resilience.
Publications: Her recent work highlights discoveries such as LDHB’s role in insulin secretion regulation and GC-globulin’s role in alpha cell adaptation. She employs innovative techniques like fluorescent probes and photochromic compounds to study cellular processes.
Awards: Her Diabetes UK fellowship supports her pioneering research bridging basic science and clinical applications. Her lab, the Islet Biology Lab, hosts interdisciplinary collaborations and DPhil projects.
Grants & Labs: Active in securing research grants and mentoring early-career scientists. Her team’s findings aim to uncover novel therapeutic targets for diabetes treatment.
