Daniel Notterman

Daniel Notterman is a Professor of the Practice in Molecular Biology and Senior Advisor to the Provost for Biomedical Affairs at Princeton University. He holds dual affiliations with the Department of Molecular Biology and serves as a Senior Research Scholar. His research focuses on genetic, epigenetic, and environmental interactions influencing child development and health outcomes, particularly through the lens of the Fragile Families and Child Wellbeing Study (FFS), a longitudinal cohort tracking 5,000 children across socioeconomic contexts. Key areas include telomere dynamics, DNA methylation, and the biological embedding of social adversity. Notterman's lab investigates mechanisms linking early-life stress to lifelong health disparities, including studies on postpartum depression, autism genetics, and sepsis pathophysiology.

His work integrates clinical pediatrics with molecular biology, emphasizing translational research to address public health challenges. Notable collaborations include the ICU-RESUS clinical trials on pediatric resuscitation protocols and the Methylation, Imaging and NeuroDevelopment (MIND) Consortium. He advises on biomedical policy at Princeton and maintains an active role in precision health initiatives.

Research highlights include demonstrating how adverse environments accelerate telomere shortening and identifying epigenetic mediators of socioeconomic health gaps. Notterman's lab also explores inborn errors of immunity in pediatric sepsis and develops low-cost medical technologies like the PVP1 ventilator.

Professional service includes leadership roles in pediatric critical care research networks and mentorship of trainees in interdisciplinary health sciences. His contributions bridge basic science and clinical practice, addressing societal inequities through biological mechanisms.