Daniel Kaufmann

Dr. Daniel E. Kaufmann is a Full Professor at the University of Montreal, operating through the CRCHUM (University of Montreal Hospital Research Center) and its Immunopathology Research Axis. He holds dual appointments in the Departments of Medicine and Microbiology, Infectious Diseases and Immunology, combining clinical expertise as an Infectious Disease Consultant at CHUM with cutting-edge research.

His laboratory specializes in CD4 T cell immunobiology during HIV infection, investigating immune exhaustion mechanisms (PD-1, CTLA-4, IL-10 pathways) and developing innovative tools like RNA-FISH flow cytometry for single-cell viral reservoir tracking. Recent work extends to SARS-CoV-2 immunopathology, including breakthrough infection dynamics in immunocompromised individuals.

Key research areas:

• T cell dysfunction in chronic viral infections
• Viral reservoir characterization
• Immunotherapeutic strategies for HIV/COVID-19
• Host genetics of critical SARS-CoV-2 outcomes

Scientific accolades:

• Fonds en Recherche Québec Santé (FRQS) Merit Researcher
• Grants from CIHR, NIH, CFI, and Bill & Melinda Gates Foundation

Academic leadership: Serves on international review committees for grants and journals, while mentoring students at all levels in immunovirology techniques and analysis.