معرفی
Daniel D. Lee, PhD serves as an Instructor in the Department of Pathology and Immunology at Washington University School of Medicine, specializing in the Immunobiology division.
Education:
- B.S. in Biochemistry and Molecular Biology, Biology: University of Georgia, Athens, Georgia
- Ph.D. in Cellular and Integrative Physiology: Indiana University School of Medicine, South Bend & Indianapolis, Indiana
- Postdoctoral Fellowship: Washington University School of Medicine, St. Louis, Missouri
Dr. Lee pioneers advanced 3D biomedical imaging techniques to visualize physiological and clinical mechanisms through non-invasive and biopsy approaches. His research centers on three innovations: rapid tissue transparency preparation using non-toxic methods, efficient image acquisition from transparent tissues, and advanced image processing for enhanced resolution. He developed ADAPT-3D (Accelerated Deep Adaptable Processing of Tissue for 3-Dimensional Fluorescence Tissue Imaging), which achieves tissue transparency in one week while preserving morphology—dramatically faster than conventional methods. This enables unprecedented visualization of microvascular structures in organs like brain, heart, and intestines for diseases including Crohn's and cerebral amyloid angiopathy. His work with Scientific Volume Imaging Huygens optimizes deconvolution techniques for deep-tissue imaging up to 500 microns, delivering near-confocal resolution at minimal cost.
Scientific Recognition:
- BRAIN Initiative K99/R00 Awardee (2021)
- Leading Edge Fellow (2020)
Dr. Lee's BRAIN Initiative K99/R00 grant supports his development of 3D imaging frameworks for neurological research. His clinical applications include rapid 3D kidney biopsy analysis for improved glomerular visualization and enhanced PET lymphatic imaging. He maintains active collaborations with industry partners like Scientific Volume Imaging Huygens and interdisciplinary medical teams to translate imaging breakthroughs into clinical pathology workflows.
