Daniel B. Vigneron

Daniel B. Vigneron, PhD is a Professor at the University of California, San Francisco (UCSF) Department of Radiology and Biomedical Imaging. He serves as Director of the Hyperpolarized MRI Technology Resource Center (HMTRC), Director of Human Imaging Core Services, Director of Advanced Imaging Technologies SRG, and Operations Director of the Surbeck Laboratory for Advanced Imaging. As a core member of the UCB/UCSF Graduate Group in Bioengineering, Vigneron has established himself as a leader in molecular imaging research with over three decades of experience at UCSF.

Vigneron's research focuses on developing advanced functional and metabolic MRI techniques, particularly hyperpolarized carbon-13 technology, for studying prostate cancer, brain tumors, and other diseases. His work enables non-invasive imaging of metabolic processes, allowing clinicians to monitor therapy effectiveness and guide treatments. The HMTRC, which he founded in 2011 with NIH funding and recently secured a 5-year renewal for, has supported 20 external projects domestically and 15 internationally, produced 239 publications, and trained 149 researchers. Vigneron's lab develops novel coil and software techniques for high-field MRI, MR spectroscopy, and diffusion imaging at 3T and 7T for studying brain, prostate cancer, and other organs.

His recent publications demonstrate a clear trajectory toward clinical translation of hyperpolarized carbon-13 MRI across multiple organ systems. The research spans abdominal imaging with advanced denoising techniques, cardiac metabolism studies, whole-brain coverage applications, and cerebral perfusion analysis. This work represents a significant shift from basic science toward practical clinical applications in oncology, cardiology, and neurology, with particular emphasis on standardization for multi-center studies.

Scientific Awards:

• 2022 Outstanding Faculty Mentoring Award from UCSF Department of Radiology and Biomedical Imaging

Vigneron has mentored 149 trainees throughout his career, with several former students now serving as faculty members including Duan Xu, Peder Larson, and Susan Noworolski. As Principal Investigator overseeing eight grants, he has secured significant NIH funding for the HMTRC and other research initiatives. His administrative leadership extends to co-chairing the department's Safety and Compliance Committee, where he has helped establish robust safety protocols for PET-MR programs. Vigneron's mentoring philosophy emphasizes adapting to individual needs at different career stages, moving from instructor to coach to manager to cheerleader as trainees progress.

The Vigneron Lab, located in Byers Hall on the UCSF Mission Bay campus, operates within the Surbeck Laboratory for Advanced Imaging. The lab group develops novel acquisition techniques and hardware for multinuclear MR spectroscopy, with particular focus on hyperpolarized carbon-13 metabolic imaging. The HMTRC serves as a hub for team science, bringing together researchers from diverse disciplines to advance metabolic imaging technology and its clinical applications.