معرفی
Danesh Moazed is a Professor of Cell Biology and HHMI Investigator at Harvard Medical School (HMS), affiliated with the Harvard Biophysics Program and Harvard Initiative for RNA Medicine (HIRM). He holds a Ph.D. from the University of California, Santa Cruz, and conducted postdoctoral research at UCSF. His research focuses on epigenetic inheritance of heterochromatin in yeast and mammalian systems, exploring mechanisms of gene silencing and chromatin regulation. Moazed’s work integrates genetics, genomics, and structural biology to uncover conserved principles of heterochromatin assembly and function.
Education:
- Ph.D., University of California, Santa Cruz
- Bachelor’s Degree, University of California, Santa Cruz
- Postdoctoral Studies, University of California, San Francisco
Research Interests:
Moazed’s lab investigates heterochromatin-mediated gene silencing, including studies of Sir proteins in budding yeast, RNAi-dependent pathways in fission yeast, and HP1-mediated mechanisms in mammalian cells. Key areas include:
- Epigenetic stability and inheritance across generations
- Structural and functional analysis of chromatin complexes
- Role of histone modifications and RNA processing in heterochromatin formation
Grants & Funding:
Principal Investigator on NIH grants including:
- R35GM122524: RNA Processing Machines in Biology and Disease (2017–2023)
- R01GM072805: Epigenetic Inheritance of Heterochromatin (2005–2025)
Labs & Collaborations:
Moazed directs the Moazed Lab at HMS, collaborating with researchers in proteomics, structural biology, and epigenetics. His work contributes to understanding fundamental chromatin dynamics and their implications in disease and development.
