معرفی
Dan Landau serves as Associate Professor at Weill Cornell Medicine's Graduate School of Medical Sciences with dual appointments in Physiology, Biophysics & Systems Biology and Computational Biology programs.
His Landau Lab pioneers research in evolutionary biology of mammalian cells, specifically investigating cancer as a 'reverse engineering' phenomenon where cells rescind multicellular contracts. The lab examines how evolutionary plasticity limits cancer therapies and seeks to chart fundamental dimensions of tumor evolution to develop anticipatory treatments. Current research focuses on somatic cell evolution across functional, temporal, and spatial dimensions using advanced genomics technologies.
Key projects include mapping genotypes to molecular phenotypes through single-cell multiomics to understand how somatic mutations disrupt gene expression, mRNA splicing, and epigenetic regulation in human clonal outgrowths. The lab has developed innovative tools for quantifying cancer plasticity and enabling cancer monitoring via blood tests.
Dr. Landau actively mentors graduate students, including Joe Pelt who received the 2024 ASH Graduate Hematology Award. His research bridges computational biology with physiological systems through the Tri-Institutional partnership with Sloan Kettering Institute.
