معرفی
Dr. Damien Freyssenet is a Professor at Université Jean Monnet in Saint-Étienne and leads the DeReM-SE research team at the Laboratoire Interuniversitaire de Biologie de la Motricité. His research focuses on muscle deconditioning in physiological and pathological contexts, including cancer, myopathies, and intensive care. He has made significant contributions to understanding myostatin's role in muscle homeostasis and systemic metabolic disturbances.
Research Interests: His work centers on the mechanisms of skeletal muscle deconditioning, particularly the role of myostatin in regulating protein synthesis and degradation. He investigates how muscle wasting affects systemic metabolism, especially liver function, with an emphasis on glucocorticoid involvement in cancer and sepsis. Recent interests include gender differences in centro-nuclear myopathy-related deconditioning.
Publication Trends: His research spans molecular physiology, metabolic regulation, and translational models of disease. Key themes include myostatin signaling, mitochondrial function, proteolysis, and endocrine control in muscle-wasting conditions. Much of his work uses animal models to explore therapeutic strategies for preserving muscle mass.
Scientific Funding:
- Association Française contre les Myopathies (AFM)
- Fondation ARC pour la Recherche sur le Cancer
- Ligue contre le Cancer
- Centre National des Études Spatiales (CNES)
Advising and Grants: He has directly supervised 14 PhD theses and served as an external reviewer in over 60 doctoral and HDR defenses. His sustained funding reflects strong recognition in muscle physiology and metabolic disease research.
Labs and Teams: He heads the DeReM-SE (Deconditioning Reconditioning of skeletal Muscle - Systemic Environment) team, which investigates the interplay between muscle health and systemic metabolism under stress conditions.
