معرفی
Dale Haines, PhD, is an Associate Professor at the Lewis Katz School of Medicine at Temple University. He holds dual appointments in the Department of Medical Genetics and Molecular Biochemistry and the Department of Biomedical Education and Data Science. His research is centered on intracellular protein trafficking, particularly the ERGIC-53 pathway and its role in cellular quality control and cancer progression.
- University: Temple University
- School: Lewis Katz School of Medicine
- Departments: Medical Genetics and Molecular Biochemistry; Biomedical Education and Data Science
- Rank: Associate Professor
- Email: dale.haines@temple.edu
Dr. Haines' research interests lie at the intersection of molecular cell biology and cancer. He investigates how ERGIC-53 and its interacting partners—such as p97-UBXD1 and Rab3GAP1/2—regulate vesicular transport from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). His lab uses LC-MS/MS-based proteomics to define the cargo and regulatory mechanisms of these vesicles. A key focus is on the emerging roles of these pathways in autophagy and tumor cell metastasis, suggesting implications for therapeutic targeting in cancer.
The most recent publications (2023–2018) indicate a significant shift or expansion into vascular biology, particularly the role of FXR1 in vascular smooth muscle cells (VSMCs), where it regulates inflammation, senescence, and contractility. Earlier work (2010–2000) focused on ubiquitin-mediated protein degradation, p97 complexes, and oncogenic signaling involving MYC and p53. Collectively, his research spans protein homeostasis, cell cycle regulation, and cancer mechanisms.
While no specific scientific awards are listed in the provided text, his sustained publication record in high-impact journals such as Cell Reports, Cancer Research, and Molecular Cell suggests recognition in the field.
Dr. Haines has trained and collaborated with numerous researchers, though specific student names are not listed. His lab has received research support enabling proteomic and molecular studies, although detailed grant information is not provided. His recent collaborations with Michael V. Autieri highlight team-based cardiovascular and cancer research initiatives.
The Haines lab operates at the Fels Cancer Institute for Personalized Medicine, indicating integration into a larger cancer research ecosystem at Temple. His work bridges basic science and translational applications, particularly in identifying novel targets in cancer and vascular disease.
