DANIEL CACABELOS BARRAL

Daniel Cacabelos Barral is a Researcher at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). He obtained his Doctorate from the University of Lleida in 2014, focusing on 'Polyunsaturated fatty acids in amyotrophic lateral sclerosis: role of DHA, peroxidative modifications, and sexual dimorphism.' His research primarily investigates neurodegenerative diseases, particularly ALS, with a focus on lipid metabolism, oxidative stress, and dietary interventions. He has collaborated with mentors like Dr. Manuel Portero Otin and Dr. Reinald Pamplona.

Key research areas include mitochondrial dysfunction in neurodegeneration, the interplay between TDP-43 proteins and lipids in ALS progression, and the role of gender-specific differences in disease outcomes. His work also explores inflammation and oxidative damage in conditions like colitis and adrenoleukodystrophy, often employing mouse models to study biological mechanisms.

Major findings include the beneficial effects of docosahexaenoic acid (DHA) in ALS models and the impact of lipid unsaturation on disease survival. He has contributed to lipidome analysis in multiple sclerosis, revealing lipoxidative damage as a potential pathogenic mechanism. His studies emphasize translational approaches, linking dietary components to molecular pathways in health and disease.

Dr. Cacabelos Barral’s publications span experimental colitis treatments, mitochondrial dysfunction in genetic disorders, and the effects of caloric restriction on protein modifications. Despite no documented awards, his work has advanced understanding of oxidative stress and lipid interactions in chronic and neurodegenerative conditions.