معرفی
Professor Colin Fishwick is a faculty member at the University of Leeds, where he serves as Professor of Medicinal Chemistry and Head of the School of Chemistry. He is also an Honorary Visiting Professor at the University of Bradford’s Institute of Cancer Therapeutics and at the University of Sheffield. His work bridges computational drug design and synthetic chemistry to address major global health challenges.
Research Interests: His research focuses on medicinal chemistry, synthetic methods, chemical biology, drug design, and molecular modelling. He pioneers computational tools like SPROUT for fragment-based design and applies them to discover novel ligands for challenging targets. His work spans antimicrobial resistance (particularly against ESKAPE pathogens), neglected tropical diseases (malaria, toxoplasmosis), cardiovascular repair, and diabetes therapeutics. He integrates cryo-EM, computational biology, and synthetic chemistry to develop selective small molecules and chemical probes.
Publication Trends: His recent publications reflect a strong emphasis on combating antibiotic resistance through dual-targeting strategies and novel enzyme inhibitors. He also advances anti-parasitic drug development, particularly DHODH and mPPase inhibitors, and explores insulin signalling restoration for diabetes. His work increasingly incorporates solid-form property prediction for improved drug bioavailability.
- Scientific Awards: No specific awards mentioned in the text.
Advising and Grants: He leads a research group in Chemical Biology and Medicinal Chemistry and welcomes PhD students. He collaborates with Medicines for Malaria Venture (MMV) and the Leeds Institute of Cardiovascular and Molecular Medicine (LICAMM), indicating involvement in externally funded projects. While specific grants are not listed, his international collaborations and project descriptions imply sustained funding.
Labs and Teams: He leads the research group focused on computational and synthetic approaches to drug discovery within the School of Chemistry. He is affiliated with the Astbury Centre and collaborates across disciplines, including parasitology, cardiovascular medicine, and structural biology.
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