معرفی
Colin Conine, Ph.D. is an Assistant Professor of Pediatrics at the University of Pennsylvania's Perelman School of Medicine, with appointments in the Department of Pediatrics and affiliations with the Penn Epigenetics Institute, Penn Institute for Regenerative Medicine, Center for Research on Reproduction and Women's Health, Children's Hospital of Philadelphia (CHOP), and the Center of Excellence in Environmental Toxicology at CHOP.
Dr. Conine's educational background includes:
- BS in Biochemistry from University of Rochester (2007)
- PhD in Molecular Biology and Genetics from University of Massachusetts Medical School (2014)
Dr. Conine's research focuses on the functions of noncoding RNAs in fertility, epigenetic inheritance, and development. His lab investigates how RNAs present in sperm transmit non-genetic information to progeny, influencing offspring phenotype. Key areas include how small RNAs regulate gene expression in the male germline, how they're packaged into mature sperm, how transmitted RNAs regulate early embryonic gene expression, and how this regulation alters developmental programs to produce non-genetically inherited phenotypes. His work utilizes genomic, molecular biology, and assisted reproduction techniques across mouse, embryonic stem cell, and C. elegans models.
Analysis of Dr. Conine's recent publications reveals a strong focus on sperm RNA biology and its role in epigenetic inheritance. His work spans multiple model systems but primarily centers on mouse models of reproduction and development. A key theme is the role of epididymal extracellular vesicles in transferring RNAs to sperm during maturation. His research also explores environmental influences on sperm epigenetics, including temperature effects and microbiome interactions. These studies collectively advance our understanding of how paternal factors can influence embryonic development and offspring phenotype through non-genetic mechanisms.
Dr. Conine actively mentors several graduate students, postdocs, undergraduate researchers, and research technicians:
- Graduate students: Nick Galambos, Alexis Leach, Grace Lee, Taylor Miller-Ensminger, and Alexandra Schneider
- Postdoc: Blair Schneider
- Undergraduate researchers: Linda Chen and Kati Gross
- Research Technician: Maddie Lamonica
The Conine Lab utilizes multiple model systems including mice, embryonic stem cells, and C. elegans to investigate questions related to sperm RNA biology, epigenetic inheritance, and early embryonic development. Their research combines state-of-the-art genomic approaches, molecular biology techniques, and assisted reproduction methods to uncover fundamental mechanisms of intergenerational communication.
