معرفی
Cole Trapnell is a Professor in the Department of Genome Sciences at the University of Washington. His research focuses on advancing single-cell genomic technologies to study gene regulation and cell-cell communication during development and disease. He leads a laboratory that has pioneered methods like sci-ATAC-seq and Cicero for chromatin accessibility analysis and co-accessibility network mapping.
- Education: PhD in Computer Science from the University of Maryland, co-advised by Steven Salzberg and Lior Pachter; postdoctoral training under John Rinn at Harvard’s Stem Cell and Regenerative Biology Department.
Cole’s work spans diverse organisms, including Drosophila, zebrafish, mice, and plants, with applications in developmental biology, disease modeling, and regenerative medicine. His recent publications highlight innovations in single-nucleus isolation, CRISPR-based genetic screens, and trajectory analysis of cellular differentiation. He has also contributed to computational tools like TopHat, Cufflinks, and Monocle.
Collaborations: Cole frequently collaborates with researchers like Jay Shendure, John Rinn, and Thomas Reh. He co-founded or consults for biotech companies including Algen Biotechnologies, Altius Therapeutics, and Scale Biosciences. His software and methods are widely used in the field of single-cell genomics.
