معرفی
Clement Y. Chow is an Associate Professor at the Department of Human Genetics, University of Utah School of Medicine. His research focuses on understanding how genetic variation contributes to endoplasmic reticulum (ER) stress and disease outcomes, using Drosophila melanogaster models to inform precision medicine approaches for human conditions like NGLY1 deficiency and CMT4J.
- Director of the CARE Lab
- Collaborates with clinicians and computational biologists
His team employs quantitative genomics, CRISPR screening, and transcriptional analysis to identify therapeutic targets. Recent work explores histone methylation in ER stress preconditioning and glycosylation pathways in congenital disorders.
Key article trends include:
- ER stress modulation in neurodegenerative diseases
- Drug repurposing for rare conditions
- Evolutionary conservation of disease modifiers
- Tissue-specific genetic interactions
- Translational approaches from fly to human
- Epigenetic and metabolic regulatory mechanisms
Lab personnel include:
- Mimi Aziz (Graduate Student)
- Emily Coelho (Laboratory Manager)
- Holly Thorpe (Postdoctoral Fellow)
- Sydney Peterson (Graduate Student)
- Naomi Young (Lab Technician)
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