معرفی
Christian M. Matter is a Professor of Cardiology at the University Hospital Zurich, where he leads Translational Research and the Cardio-oncology service. A board-certified internist and cardiologist with training in Lucerne, Zurich, and Boston, he combines basic research (using cell culture and genetic mouse models) with clinical studies in myocardial infarction, heart failure, and cancer patients. His work focuses on the intersection of inflammation, immunometabolism, and atherothrombosis.
Research Interests:
- Immuno-metabolic pathways in atherothrombosis
- Role of PARP1, JNK2, Sirtuins 1/3/6 in cardiovascular disease
- Clonal Hematopoiesis of Indeterminate Potential (CHIP) in mice
- Machine learning-based risk prediction for ACS patients
- Cardio-oncology (immune checkpoint inhibitors, myocardial damage)
- Microbiome-immune-cardiovascular interactions
Collaborative Projects:
- Co-PI of Special Program University Medicine (SPUM) ACS-inflammation cohort (5,000 patients)
- Main applicant for SwissHeart Failure Network (SHFN) with ETH Zurich's Joachim Buhmann
- Collaborations with dermatology (Reinhard Dummer), immunology (Burkhard Ludewig), and microbiome experts (Michael Scharl)
Key Findings:
- Developed machine learning mortality prediction models for ACS patients
- Demonstrated SIRT3/SIRT6 protective roles in thrombosis and atherogenesis
- Elucidated PARP1/JNK2 mechanisms in endothelial dysfunction
- Identified FAP as atheroprotective target
Grants & Collaborations:
- Funded by Swiss Academy of Medical Sciences (SAMW)
- Supported by Swiss Heart Foundation
- Industry partnerships with Novartis, Sanofi-Regeneron, Amgen
- Collaborative networks in Basel, Bern, Geneva
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