Christian Jorgensen

Christian Jorgensen is a Senior Lecturer at the School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, within the Faculty of Science & Health and the Institute of Life Sciences and Healthcare. He is actively engaged in research on computational modeling of the blood-brain barrier and membrane transport processes.

• PhD in Chemistry, King's College London (2018)
• MChem, University of Oxford, Merton College (2011)
• Marie Skłodowska-Curie Fellow, Aarhus University
• Postdoctoral experience at Georgetown University and Johns Hopkins University

Dr. Jorgensen's research focuses on computational biophysics and drug delivery, particularly the development of all-atom molecular dynamics models of the blood-brain barrier. His work addresses challenges in CNS drug delivery, including multidrug resistance and neurodegenerative diseases. He investigates the role of the glycocalyx and mechanical changes in BBB integrity during disease and aging. His methodologies include unguided and steered molecular dynamics, permeability protocols, and multiscale simulations.

The 15 most recent publications reflect a consistent focus on computational modeling of biological barriers—especially the BBB and skin—with applications in drug permeability, efflux pumps (e.g., P-glycoprotein), and membrane protein dynamics. His work bridges chemistry, pharmacology, and neuroscience, with increasing emphasis on validation and benchmarking of in silico models. Emerging themes include immunometabolism and science policy, indicating interdisciplinary expansion.

Scientific Awards and Recognition:

• Marie Sklodowska Curie Fellow (European Commission)
• Fellow of the Higher Education Academy (FHEA, UK)

Service and Leadership: Dr. Jorgensen serves as Impact Lead (International) for REF 2029 submissions at both the Institute and School levels. He is an Editorial Board Member for the Journal of General Physiology (2025–2028), a Guest Editor for IJMS, and a reviewer for top journals including PNAS and JCIM. He has organized workshops and chaired panels on career development in biophysics.

Research Group: The Jorgensen Group at Portsmouth develops computational models of complex membranes to advance drug delivery systems, particularly for CNS disorders. The group integrates molecular simulations with experimental data to improve predictive accuracy in pharmacokinetics and permeability.