Chloe Cassandra Boyle

Chloe Cassandra Boyle serves as an Adjunct Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences within the UCLA School of Medicine. Her research program focuses on the intersection of inflammation, mental health, and reward processing, with particular emphasis on how inflammatory processes contribute to depression, anhedonia, and altered reward mechanisms.

Her primary research interests center on psychoneuroimmunology, examining the bidirectional relationships between the immune system and brain function. Dr. Boyle investigates how inflammatory challenges affect neural reward circuitry, with special attention to sex differences and vulnerable populations including breast cancer survivors and older adults. Her work employs experimental paradigms such as endotoxin administration and influenza vaccination to induce controlled inflammatory responses while measuring psychological and neural outcomes.

Analysis of her publication record from 2016-2024 reveals consistent research productivity with a growing focus on sex differences, aging, and translational models connecting inflammatory processes with specific depression symptoms like anhedonia. Her work frequently employs multimodal approaches combining behavioral assessments, inflammatory biomarkers, and neuroimaging techniques to elucidate mechanisms linking inflammation with altered affect and cognition.

• Psychoneuroimmunology
• Inflammation-depression relationships
• Reward processing and anhedonia
• Sex differences in stress response
• Mindfulness interventions
• Older adult mental health
• Breast cancer survivorship

Dr. Boyle maintains active collaborations with prominent researchers in the field including Michael Irwin, Steven Cole, and Patricia Ganz. Her work has received attention across multiple platforms with significant readership on Mendeley and coverage in news outlets, indicating impact within both academic and broader communities.