معرفی
Chinten James Lim is an Associate Professor at the Faculty of Medicine, University of British Columbia, affiliated with the Department of Pediatrics and BC Children's Hospital Research Institute. His research spans cancer progression and metastasis, medical and biomedical engineering, and pediatric oncology.
- Major research areas: Tumour cell biology, mechanisms of drug resistance, and tumour microenvironment interactions.
- Methodologies: Patient-derived xenografts (PDX), proteomics, and integrin biology.
Recent publications highlight his work in precision oncology, particularly using proteomics to identify treatment strategies for progressive malignancies. His team has developed personalized xenograft models to study disease evolution and therapy sensitivity in pediatric cancers.
Dr. Lim’s lab investigates drug resistance mechanisms in hematological tumors (e.g., B-ALL) and solid cancers, focusing on integrin signaling pathways (e.g., RHAMM-TPX2-Aurora A interactions) and immunophenotype stability. He also explores innovative therapies for airway inflammation and fibroblast transplantation rejection.
His work is supported by collaborations with BC Children's Hospital BioBank, Interdisciplinary Oncology Program, and Sunny Hill Health Centre. He supervises graduate students in Cell and Developmental Biology and Women+ and Children's Health Sciences programs.
