معرفی
Charles Hoffman is a Professor and Department Chair in the Biology Department at Boston College. He holds a Ph.D. from Tufts University School of Graduate Biomedical Sciences and an S.B. from MIT. His research focuses on molecular and chemical genetics using the fission yeast Schizosaccharomyces pombe as a model system. Key areas include cAMP signaling pathways, phosphodiesterase (PDE) inhibitors, and drug discovery for diseases like cancer, inflammation, and HIV. His lab develops yeast-based platforms for high-throughput screening of compounds targeting PDEs and adenylyl cyclases.
Research highlights include identifying PDE11 inhibitors (e.g., BC11-38), collaborating on brain-permeable PDE11 inhibitors for age-related cognitive decline, and screening parasite PDEs (e.g., Schistosoma mansoni, Plasmodium falciparum) for novel drug targets. His work integrates molecular genetics, biochemistry, and computational tools to study transcriptional regulation, chromatin dynamics, and noncoding RNA functions.
Recent studies explore metabolic stress-induced long noncoding RNAs in meiotic DNA breaks and revised gene nomenclature guidelines for machine readability. Hoffman collaborates with medicinal chemists and neuroscientists, emphasizing translational research to bridge basic biology with therapeutic applications.
Publications emphasize PDE inhibitors, yeast-based screening methods, and fission yeast genetics. His work underscores the utility of fission yeast as a model organism for understanding fundamental biological processes and drug development.
