معرفی
Dr. Changhai Tian is an Assistant Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky College of Medicine. His research focuses on understanding inter-organ communication via extracellular vesicles (EVs) in cardiovascular diseases, neurodegenerative disorders, and other pathologies. He investigates mechanisms by which damaged organs communicate with remote organs during disease progression, with a particular emphasis on EV-mediated cardiac-cerebral syndrome and bidirectional heart-brain interactions in conditions like Alzheimer's disease and traumatic brain injury. Dr. Tian holds a PhD from the Chinese Academy of Sciences and completed postdoctoral training at the University of Nebraska Medical Center.
Education
PhD, Chinese Academy of Sciences, P.R. China
Postdoctoral Training, University of Nebraska Medical Center, Omaha, NE, USA
Research Interests
Dr. Tian's work integrates cell biology, molecular biology, and physiology to study EV-mediated communication in disease contexts. Key areas include:
- EV roles in cardiovascular and neurological disorders
- Nrf2 regulation of oxidative stress in heart failure
- Cardiac-brain crosstalk in disease pathogenesis
- Development of EV-based therapeutics
Funding
- NIH/NHLBI R01HL153176 (MPI)
- American Heart Association 24TPA1300008 (PI)
- American Heart Association 25TPA1472723 (PI)
- Start-up funding from the University of Kentucky
Grants & Awards
His NIH and AHA grants support interdisciplinary projects exploring EV biology, Nrf2 signaling, and translational therapeutics.
Labs & Collaborations
Dr. Tian's laboratory uses transgenic mouse models and advanced cell culture systems to study EV-mediated pathophysiological mechanisms. Collaborations span cardiovascular and neuroscience research to advance understanding of organ crosstalk in disease.
