معرفی
Dr. Catherine M. Stein serves as Professor in the Department of Population and Quantitative Health Sciences at Case Western Reserve University School of Medicine, where she directs research on tuberculosis genomics and developmental speech disorders. Her work bridges genetic epidemiology, biostatistics, and clinical translation through international collaborations in Uganda and South Africa.
Education
- Ph.D. in Epidemiology and Biostatistics, Case Western Reserve University (2004)
Research Focus: Dr. Stein's program investigates tuberculosis susceptibility through host-pathogen genomic interactions, particularly in HIV-coinfected populations, and speech-sound disorder etiology via cognitive domain modeling and genetic mapping. Her development of strum R software enables advanced structural equation modeling for family-based genetic studies, featured in Nature Medicine and American Journal of Speech-Language Pathology publications.
Publication Trends: Recent work demonstrates methodological innovation in genetic epidemiology (40% in top-tier journals) with 54% international collaboration. Key themes include biomarker discovery for TB exposure, longitudinal outcomes of speech disorders, and ethical frameworks for genomic secondary findings.
Mentorship & Funding: She has trained 30 Master's students (5 mentored), 5 PhD candidates, and 1 postdoc, with alumni at Eli Lilly, NIOSH, and NYC Public Health. Current grants include NIH R01s on TB resistance in HIV+ subjects (Uganda/South Africa), NIDCD-funded speech disorder genetics, and Gates Foundation research on pediatric infection recovery.
Professional Engagement: Dr. Stein serves as Associate Editor for International Journal of Tuberculosis and Lung Disease and Biomed Central Infectious Diseases, with editorial board membership at Genes Immunity. She actively contributes to the American Society of Human Genetics Social Issues Committee.
