Casey Theriot

Casey Theriot is a Professor in the Department of Population Health and Pathobiology at the College of Veterinary Medicine, North Carolina State University. She serves as Assistant Director of the Center for Gastrointestinal Biology and Disease (CGIBD) and directs the Gnotobiotic Animal Core at NCSU, with research spanning gastrointestinal microbiology, metabolomics, and infectious disease mechanisms.

Her research focuses on gut microbiota interactions with bile acid metabolism and their ecological impact on pathogens like Clostridioides difficile. Using in vitro and in vivo models, her lab investigates how microbial-derived secondary bile acids inhibit C. difficile life cycles and develops targeted bacterial approaches to alter gut bile acid pools for therapeutic interventions against gastrointestinal diseases. This work addresses CDI as a leading nosocomial infection causing over 500,000 annual U.S. cases and 30,000 deaths.

Scientific recognition includes:

• Pilot and Feasibility Award 2015 (CGIBD)

Dr. Theriot's research is supported by the CGIBD award and focuses on rational manipulation of gut microbiota through high-throughput metabolomic and microbiome analyses. While specific grant mechanisms beyond the CGIBD award aren't detailed, her work involves mentoring researchers in gnotobiotic animal modeling despite no named advisees appearing in source materials.

The Theriot Lab operates within NCSU's veterinary infrastructure, utilizing advanced techniques to study microbiome-metabolome interactions in CDI pathogenesis, with facilities located at 1060 William Moore Drive in Raleigh.