Carrie L Lucas

Carrie L Lucas is an Associate Professor of Immunobiology at Yale University School of Medicine. She holds primary tenure in the Department of Immunobiology and is affiliated with multiple research centers including the Yale Cancer Center, Yale Center for Genomic Health, Yale Center for Immuno-Oncology, and the Yale Center for Systems and Engineering Immunology (CSEI). Dr. Lucas received her PhD from Harvard University and completed her postdoctoral training at the National Institutes of Health, NIAID.

Dr. Lucas's research focuses on discovering single-gene defects underlying severe immune disorders in humans. Her laboratory employs human genomics, in vitro studies with primary patient cells, and in vivo mouse modeling approaches to uncover fundamental immunological principles. Her specific research interests include hereditary autoinflammatory diseases, immunologic deficiency syndromes, immunoproliferative disorders, inflammation, signal transduction, and T-lymphocyte biology.

Analysis of Dr. Lucas's recent publications reveals a strong emphasis on genetic immunodeficiencies, particularly those involving the PI3K pathway (including PI3Kγ and PI3Kδ), as well as studies on autoinflammatory conditions like ELF4 deficiency. Her work bridges basic science with clinical applications, exploring how genetic errors illuminate fundamental immune mechanisms and potential therapeutic targets.

Her notable scientific awards include the Enders Faculty Fellow (2023), Christina Fleischmann Award to Young Women Investigators (2020), CRI CLIP Award (2019), Bohmfalk Scholar at Yale School of Medicine (2018), and the Charles Hood Foundation Child Health Research Award (2017).

Dr. Lucas is actively involved in several research teams and clinical trials, including the Pediatric Genomics Discovery Program. Her work demonstrates significant collaboration across immunology, genetics, and clinical medicine, with frequent co-authorship with researchers from Yale's Immunobiology department, Human and Translational Immunology Program, and Yale Cancer Center.