معرفی
Dr. Carolyn Fredericks is an Assistant Professor of Neurology at Yale University School of Medicine, specializing in cognitive and behavioral disorders. She is affiliated with multiple prestigious research centers at Yale including the Alzheimer's Disease Research Center (ADRC), Center for Brain & Mind Health, Center for Neuroepidemiology and Clinical Neurological Research, and the Clinical Neuroscience Imaging Center (CNIC). Her clinical work focuses on diagnosing and treating patients with Alzheimer's disease, memory disorders, frontotemporal disease, and rarer brain disorders such as posterior cortical atrophy and logopenic progressive aphasia.
Dr. Fredericks received her MD from Stanford University School of Medicine in 2010, following undergraduate degrees in Classics and Neuroscience from Brown University. She completed her residency at Johns Hopkins Hospital and University of California, San Francisco, and a fellowship at UCSF's Memory and Aging Center. She is board certified in both Neurology (2014) and Behavioral Neurology & Neuropsychiatry (2018).
Dr. Fredericks' research focuses on preclinical Alzheimer's disease and less common Alzheimer's variants, using advanced imaging tools to understand how Alzheimer's disease progresses through functional networks in the brain. Her lab employs neuroimaging techniques to investigate how atypical Alzheimer's disease spreads across brain networks, with particular interest in posterior cortical atrophy and logopenic aphasia. She has a special interest in understanding the role of small brain structures like brainstem and thalamic nuclei in functional network abnormalities in Alzheimer's disease. Her work aims to enable earlier identification of illness, precise monitoring for future drug studies, and identification of treatment targets, particularly for patients with atypical variants of Alzheimer's disease.
Analysis of Dr. Fredericks' recent publications reveals a strong focus on Alzheimer's disease neuroimaging, with particular emphasis on functional connectivity, tau pathology, and atypical Alzheimer's variants. Her research integrates advanced neuroimaging techniques with clinical assessments to better understand disease mechanisms. A significant portion of her work examines sex differences in brain connectivity and cognitive outcomes, as well as the relationship between specific neural network abnormalities and clinical symptoms. Her research bridges basic neuroscience with clinical applications, aiming to develop better diagnostic tools and treatment targets.
- Principal Investigator: Network Integrity in Neurodegenerative Disease (HIC ID 2000032137)
- Sub Investigator: Study of Brain Function Across the Lifespan (HIC ID 2000020891)
Dr. Fredericks leads the Fredericks Lab at Yale, which is affiliated with several key research centers including the Yale School of Medicine, Yale Clinical Neurosciences Imaging Center, Yale Magnetic Resonance Research Center, Yale Alzheimer's Disease Research Center, Yale Positron Emission Tomography Center, Yale Center for Clinical Investigation, and the Wu Tsai Institute. Her lab's work is supported by multiple research grants focused on understanding Alzheimer's disease progression through advanced neuroimaging techniques.
