Caroline Graff

Caroline Graff is Professor of Genetic Dementia Research at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. She is also a Specialist Physician at Karolinska University Hospital and leads the Translational Genetics of Neurodegenerative Disease research group. She has been the head of the Karolinska Institutet Brain Bank since 2011 and is actively involved in national and international research networks such as GENFI, IGAP, and EADC.

• Medical Degree, Uppsala University, 1992
• PhD in Clinical Genetics, Uppsala University, 1997
• Docent, Karolinska Institutet, 2007

Her research focuses on the genetics and neuropathology of neurodegenerative diseases, particularly Alzheimer’s disease, frontotemporal dementia (FTD), and ALS. She investigates inherited forms of dementia to identify genetic risk factors and develop biomarkers for early diagnosis. Her work integrates clinical follow-up of families, whole-genome sequencing, and neuropathological analysis of brain tissue. She emphasizes translational research, bridging patient studies with laboratory findings.

Recent publications highlight her contributions to understanding genetic modifiers (e.g., TMEM106B), fluid biomarkers (CSF, plasma), and neuroimaging changes in presymptomatic and symptomatic carriers of FTD and Alzheimer’s mutations. Her studies frequently involve large international consortia and longitudinal cohorts like GENFI, enabling high-impact insights into disease progression and heterogeneity.

She has supervised multiple doctoral students whose work spans biomarker discovery, genetic characterization, and clinical phenotyping in dementia. Her leadership in the Brain Bank ensures access to high-quality human brain tissue for neuropathological validation.

Caroline Graff has no listed scientific awards in the provided text. However, her extensive publication record in top-tier journals and leadership roles reflect significant scientific recognition. She collaborates widely across Europe and North America, contributing to major clinical and genetic initiatives in neurodegeneration.