معرفی
Caroline Demangel is a leading researcher at the Institut Pasteur, where she heads the Immunobiology and Therapy Laboratory. Her work focuses on understanding how mycobacterial pathogens like Mycobacterium tuberculosis and M. ulcerans interact with the human immune system, with implications for infectious disease, cancer therapy, and immune modulation. She has established herself as a key figure in both basic and translational immunology.
Her research interests span immunobiology, host-pathogen interactions, vaccine development, and the emerging role of lipid droplets in immune signaling. By studying how pathogens evade immunity, she identifies novel mechanisms that can be harnessed for therapeutic intervention—such as the discovery that mycolactone, a toxin from M. ulcerans, targets the translocon complex, offering a new strategy for killing multiple myeloma cells.
The most recent publications highlight a shift toward translational applications, particularly in cancer immunotherapy and anti-infective strategies. Her work increasingly integrates molecular biology, immunometabolism, and drug discovery, reflecting a multidisciplinary approach to solving complex biomedical problems.
- Roux Fellowship
- European Research Council (ERC) Grant
Caroline Demangel leads a 12-member research team and has secured major funding, including an ERC grant, to explore lipid droplets in immunity. Her lab has contributed to the development of a startup focused on cancer therapeutics derived from mycobacterial research. She actively mentors researchers and promotes scientific innovation through academic-industry partnerships.
She co-founded a gender equality working group at the Institut Pasteur in 2019, contributing to the institution’s Gender Equality Plan aimed at improving representation of women in senior scientific roles. Her advocacy underscores her commitment to institutional change and inclusive scientific leadership.
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