معرفی
Carol Artlett, PhD, is an Associate Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine. Her research focuses on fibrosis mechanisms, particularly in systemic sclerosis (SSc), emphasizing inflammasome signaling, collagen export pathways, and miR-155 regulation. She investigates therapeutic development for fibrotic diseases and chronic wound healing, leveraging small molecule compounds and biotech collaborations.
Education:
- PhD - University of London (1996)
Research Interests:
- Inflammasome signaling pathways
- Role of miR-155 and IL-1 in fibrosis progression
- Procollagen export via TANGO1/cTAGE5 proteins
- Anti-fibrotic drug development targeting ER-Golgi transport
- Chronic wound healing mechanisms
- Systemic sclerosis pathogenesis
Key Contributions:
- Identified TANGO1 as critical for fibrosis-related collagen secretion
- Developed anti-fibrotic small molecule targeting ER protein export
- Discovered caspase-1's role in inflammasome-driven fibrosis
- Validated acALY18 peptide's anti-fibrotic potential
- Studied NLRP3 inflammasome regulation in fibroblasts
Labs/Teams:
Leads a multidisciplinary lab focusing on translational research in fibrosis mechanisms, collaborating with biotech firms to advance therapeutic candidates. Research integrates cellular immunology, molecular biology, and preclinical drug testing.
