معرفی
Carmen Domene is a Professor in the Department of Chemistry at the University of Bath, where she leads computational research on biological systems using advanced simulation techniques. Her work bridges theoretical chemistry and experimental biophysics, focusing on microscopic mechanisms of biochemical processes. She actively collaborates with experimental groups worldwide and currently accepts doctoral students.
Education
- PhD in Chemistry, Doctor of Science, University of Exeter (1998-2000, awarded 2001)
- Postgraduate Certificate in Academic Practice, King's College London (2013-2014)
- Licenciatura en Quimica, Master of Chemistry, Universidad de Sevilla (1990-1995)
- Postgraduate courses in Physical Chemistry, Universidad de Sevilla (1996-1997)
Domene's research centers on computational biophysics of membrane proteins and biological systems. She develops novel simulation methodologies including free energy calculations, enhanced sampling, and QM/MM techniques to study ion channels, enzymes, and transporters. Her approach integrates quantum chemistry, statistical mechanics, and spectroscopy to interpret experimental data and design new experiments. Current work emphasizes potassium channels, HIV antibody mechanisms, and drug-target interactions.
Recent publications (2024-2025) reveal a strong focus on molecular dynamics applications to membrane protein function, spanning ion channel gating, glucose transport mechanisms, HIV neutralization, and cancer therapeutics. Her work consistently combines computational innovation with biological relevance, utilizing high-performance computing to address complex biochemical questions across biophysics, pharmacology, and structural biology.
Scientific Awards
- Newton Advanced Fellowship from The Royal Society (2017-2018)
Domene has secured significant research funding including The Royal Society's Newton Advanced Fellowship and the 'Insights on TRP gating' project (2020-2023). She maintains an active doctoral supervision program and collaborates internationally, evidenced by her Visiting Research Academic position at the University of Oxford (2012-2023). Her research group develops specialized simulation tools while engaging with experimental teams to validate computational predictions.
Her computational chemistry group at Bath focuses on membrane protein dynamics, utilizing high-performance computing resources to investigate ion channel permeation, drug binding mechanisms, and conformational changes in biological macromolecules. Current projects address TRP channel modulation, HIV antibody neutralization, and cancer drug design through integrated computational-experimental approaches.
