Carlos Bas Orth

Prof. Dr. Carlos Bas Orth is a Professor at the Institute for Clinical Neuroanatomy, part of the NeuroScienceCenter at Goethe University Frankfurt in Germany. His laboratory is located at Haus 89, Heinrich Hoffmann Str. 7, 60528 Frankfurt am Main, with contact via phone (+49 (0)69 6301-6916) and email.

His research investigates how synaptic activity triggers neuronal adaptations through gene expression changes. Specific interests include:

• Metabolic plasticity mechanisms linking neuronal activity to energy metabolism
• Activity-dependent transcriptional control of mitochondrial stress resistance
• Disruptions in metabolic pathways during aging and neurological disorders
• Neuroprotective adaptations through synaptic-to-nuclear signaling

Methodologically, his team employs multiparametric live imaging (tracking Ca²⁺, mitochondrial redox status, ATP levels), molecular biology techniques (qRT-PCR, spatial transcriptomics), biochemical metabolic assays, viral gene transfer, and neuroinflammation models using hippocampal neurons and brain slices.

His publications consistently explore mitochondrial function, calcium signaling dynamics, and activity-dependent metabolic reprogramming in neurons, with recent work emphasizing therapeutic targeting of metabolic pathways.