Carlo Colantuoni

Carlo Colantuoni is an Assistant Professor in the Department of Neurology at the Johns Hopkins University School of Medicine. He is based at Johns Hopkins Hospital in Baltimore, MD, and leads a research lab focused on functional genomics and computational neuroscience. His work is affiliated with the Neuroscience Training Program and centers on understanding human brain development and disease through multi-omic data analysis.

His research interests include Developmental Neuroscience, Systems and Computational Neuroscience, Neurobiology of Disease, and Functional Genomics. He develops and applies advanced computational methods such as Structured Joint Decomposition (SJD) and projectR to analyze large-scale transcriptomic datasets.

Colantuoni's recent publications focus on neocortical development, stem cell variation, neuroinflammation, and host immune responses. His work integrates data from in vivo mammalian development and in vitro cerebral organoid models to identify conserved molecular dynamics and human-specific features. He has contributed to public resources like NeMO Analytics, enabling broad access to curated datasets and analytical tools.

He collaborates with leading researchers such as Gabriel Santpere, Nenad Sestan, Pasko Rakic, Flora Vaccarino, and Dimitri Avramopoulos on projects involving neurodevelopmental risk genes and neuronal identity. His lab also works with applied mathematicians Don Geman and Laurent Younes on cell type marker identification using the CellCover method.