معرفی
Candice Botuha is a Lecturer at Sorbonne University within the IPCM-UMR 8232 research unit, actively contributing to the CHEMBIO team. Her work bridges synthetic chemistry with biological applications, focusing on molecular tool development for biomedical research.
Her academic journey includes:
- PhD in Organic Chemistry from the University of Geneva (2002) under Prof. E.P. Kündig
- Postdoctoral fellowship at the University of Bristol (2002-2003) with Prof. T. Gallagher
- Postdoctoral fellowship at ICSN, Gif-sur-Yvette (2003-2004) with Joëlle Dubois
- Accreditation to Direct Research (HDR) in 2017
Dr. Botuha's research centers on medicinal chemistry and bioimaging probe development, specializing in 1,2,4-triazole-based compounds and ESIPT fluorescent dyes. Her work spans heterocyclic synthesis, organometallic chemistry, and chemical biology, targeting applications in neurodegenerative disease research, oxidative stress detection, and cancer therapeutics. Key methodologies include in silico design, chemical proteomics, and advanced spectroscopic characterization.
Analysis of her 11 most recent publications (2019-2025) reveals dominant trends in fluorescent probe engineering (73% of works) for biomarker detection and medicinal chemistry (27%) targeting neurodegenerative disorders and cancer. Her research consistently integrates heterocyclic scaffold design with biological validation, demonstrating strong interdisciplinary collaboration across chemistry, biology, and medicine.
As an active member of the CHEMBIO team, she contributes to four core research pillars:
- Synthesis of novel heterocyclic systems
- Medicinal chemistry for therapeutic development
- Protein engineering and artificial metalloenzymes
- Multidisciplinary collaborative projects
