Bryan L. Copple

Bryan L. Copple is an Associate Professor in the Department of Pharmacology and Toxicology at Michigan State University. His work focuses on hepatotoxicity, immunotoxicology, and liver inflammation mechanisms.

• Education: B.S. in Biology (1991, Morningside College); Ph.D. in Pharmacology (1997, University of Nebraska Medical Center)

Research Interests span two major areas:

• Role of Early Growth Response Factor-1 (Egr-1) in mediating bile acid-induced liver inflammation and fibrosis
• Regulation of Hypoxia-Inducible Factors (HIF-1α) during chronic liver injury and extracellular matrix deposition

His publication trends emphasize immune cell dynamics in liver failure, bile acid signaling, transcriptional regulators like HIF and Egr-1, and mechanistic toxicology. Articles explore topics from acetaminophen overdose pathophysiology to LPS sensitivity in hepatic macrophages, with a consistent focus on inflammatory and fibrotic liver diseases.

Advising and Collaborations: While no direct student names appear in the text, his work involves collaborative projects with researchers like Catherine E. Rockwell, James A. Luyendyk, and Kari Roth on liver injury mechanisms.