معرفی
Brian Perrino serves as an Associate Professor in the Department of Physiology and Cell Biology at the University of Nevada, Reno School of Medicine, where his research bridges molecular signaling and physiological function in gastrointestinal and urinary systems.
Education:
- B.S. in Biology from Syracuse University
- Ph.D. from Boston University
- Post-Doctoral training at the Vollum Institute
His research program centers on signaling pathways regulating cellular responses, with groundbreaking work on Mfge8-mediated regulation of stomach emptying. By inhibiting Rho kinase, Mfge8 increases myosin phosphatase activity and decreases gastric muscle contractions, optimizing nutrient absorption. This mechanism extends to diabetic gastroparesis and obesity-related gastric dysfunction, while parallel investigations explore PDGFRα+ cells in bladder pathophysiology and interstitial cells of Cajal in gut motility.
Analysis of his 2020-2025 publications reveals consistent focus on smooth muscle contractility mechanisms across organ systems, with innovative approaches including spatial gene mapping, transcriptomic profiling, and functional assays in murine/non-human primate models. His work identifies critical pathways in bladder fibrosis, gastric emptying regulation, and neurogenic bladder dysfunction.
Dr. Perrino has not listed any scientific awards in the provided materials.
While specific advising details are unavailable, his extensive publication record suggests active mentorship in smooth muscle research. His work is institutionally supported through the Department of Physiology and Cell Biology, with potential external funding indicated by sustained research output.
His laboratory integrates molecular characterization, functional physiology, and translational approaches to investigate smooth muscle signaling in gastrointestinal and urinary systems, maintaining strong emphasis on pathological conditions like diabetic complications and bladder inflammation.
