Brandon K. Hadland

Dr. Brandon K. Hadland is an Associate Professor at the University of Washington School of Medicine in Pediatrics and Fred Hutchinson Cancer Center's Translational Science and Therapeutics Division, with memberships in the Immunotherapy and Translational Data Science Integrated Research Centers. He serves as an Attending Physician at Seattle Children's Hospital for Pediatric Hematology/Oncology and Bone Marrow Transplant.

Education:

• BS in Chemistry, Harvey Mudd College (1998)
• MD and PhD in Molecular Cell Biology, Washington University School of Medicine (2006)
• Pediatrics Residency and Internship, Seattle Children's/University of Washington (2006-2009)
• Pediatric Hematology/Oncology Fellowship, Seattle Children's/University of Washington/Fred Hutch (2009-2012)

His research centers on embryonic hematopoietic stem cell (HSC) development, investigating Notch signaling pathways, vascular microenvironments in the AGM region and fetal liver, and engineering in vitro platforms to model blood formation. He employs single-cell functional and molecular techniques to characterize niche interactions and transcriptional programs driving HSC emergence.

Recent publications demonstrate trends in applying single-cell transcriptomics to define HSC-competent hemogenic endothelium and develop stromal-free engineered niches, bridging developmental biology with therapeutic applications for blood disorders and leukemia.

Dr. Hadland leads collaborative research across Fred Hutch and UW, partnering with experts in computational genomics (Dr. Cole Trapnell), stem cell engineering (Drs. Sergei Doulatov and Ying Zheng), and pediatric oncology (Drs. Soheil Meshinchi and Irv Bernstein) to advance cellular therapies and leukemia prevention strategies.