Bernardo Trigatti

Bernardo Trigatti is a Professor in the Department of Biochemistry & Biomedical Sciences at McMaster University's Faculty of Health Sciences. His research has established him as a leading expert in lipoprotein metabolism and cardiovascular disease mechanisms, with a specific focus on the Scavenger Receptor Class B Type I (SR-BI) and its role in HDL metabolism, cholesterol transport, and atherosclerosis development.

Dr. Trigatti's research spans over three decades, beginning with early work on fatty acid uptake mechanisms in the 1990s and evolving into sophisticated studies of SR-BI function in cardiovascular disease. His laboratory has made seminal contributions to understanding how SR-BI regulates HDL metabolism, macrophage function in atherosclerotic plaques, and protection against cardiotoxicity. His work frequently employs genetically modified mouse models, particularly SR-BI knockout mice, which have become standard tools in cardiovascular research. Recent publications demonstrate continued innovation in the field, with studies examining novel therapeutic approaches for atherosclerosis and exploring the intersection between lipid metabolism and inflammatory pathways.

The trajectory of Dr. Trigatti's scholarly work reveals an increasingly sophisticated understanding of the molecular mechanisms connecting HDL metabolism with cardiovascular disease. His early research established fundamental mechanisms of lipid transport, while more recent work has expanded into therapeutic applications, examining how modulation of SR-BI signaling could protect against atherosclerosis, myocardial infarction, and drug-induced cardiotoxicity. His 2021-2025 publications show particular interest in the relationship between HDL function and inflammatory processes, with studies examining how HDL signaling affects macrophage survival in atherosclerotic plaques and how SR-BI interactions with other receptors (like S1PR1) mediate protective effects.

Dr. Trigatti has taught courses including Drug Discovery and Development (BIOMEDDC 3B06A/B) and Inquiry II: Biochemistry (HTHSCI 2E03), demonstrating his commitment to training the next generation of biomedical scientists. His scholarly impact is evident in the widespread citation of his work across multiple disciplines and its recognition by news outlets and scientific platforms.