معرفی
Geoff Werstuck is a Professor in the Department of Medicine at McMaster University. His primary affiliation is within the Faculty of Health Sciences, where he focuses on cardiovascular and metabolic disease research. His work examines the molecular mechanisms linking diabetes mellitus to accelerated atherosclerosis, with particular attention to endoplasmic reticulum (ER) stress pathways and glycogen synthase kinase-3 (GSK-3) signaling.
Research Interests: Dr. Werstuck’s studies investigate how chronic hyperglycemia, sex hormones, and metabolic disturbances drive cardiovascular complications. Key areas include ER stress-induced cellular dysfunction, macrophage polarization in atherosclerosis, and the role of GSK-3α/β in vascular pathologies. His work integrates mouse model studies with molecular biology techniques to unravel disease mechanisms.
Recent Articles Focus: Over the past decade, his publications emphasize:
- Sex hormone effects (estrogen/testosterone) on atherosclerosis progression
- ER stress-GSK-3β cross-talk in vascular inflammation
- Diabetes-associated vascular complications, including vasa vasorum neovascularization
- Pharmacological interventions targeting metabolic syndrome and atherosclerosis
Teaching: He has consistently taught the Inquiry II: Biochemistry course (HTHSCI 2E03) at McMaster since 2018, contributing to medical student education in biomolecular sciences.
Future Work: Current projects explore sexual dimorphism in diabetes-related cardiovascular risks and novel therapeutic targets for ER stress modulation in atherosclerosis.
