معرفی
Bernadette Holdener is a Professor in the Department of Biochemistry and Cell Biology at Stony Brook University. Her research focuses on the role of O-linked glycosylation in developmental biology, particularly how rare sugar modifications influence brain, lung, skeletal, and cardiovascular system development.
Her laboratory uses transgenic mouse models to investigate how disruptions in glycosylation pathways affect extracellular matrix composition and cell signaling, leading to developmental disorders such as chondrodysplasias, hydrocephalus, bronchopulmonary dysplasia, and Marfan’s disease.
Recent work has identified key roles for:
- POGLUT2/3 in EGF O-glucosylation and digit separation via fibrillin network remodeling
- B3GLCT and POFUT2 in O-fucosylation of thrombospondin type I repeats, impacting bone and brain development
- ADAMTS family proteins in extracellular matrix remodeling and signaling
Her publications span high-impact journals including Developmental Biology, Journal of Biological Chemistry, Glycobiology, Matrix Biology, and Human Molecular Genetics, demonstrating a consistent focus on glycobiology and developmental mechanisms.
The Holdener lab is located in the Centers for Molecular Medicine at Stony Brook University, with office and lab contact information provided for direct collaboration inquiries.
