Benjamin Weaver

Benjamin Weaver is an Assistant Professor in Pharmacology at UT Southwestern Medical Center, holding the Virginia Murchison Linthicum Scholar endowment. His lab investigates gene-environment interactions using C. elegans, cell cultures, and murine models, focusing on caspase-mediated regulation of stress resolution and stem cell fate.

Key discoveries include proteolytic activation of fatty acid synthase (FASN) for pan-stress recovery and non-apoptotic caspase functions in antagonizing p38 MAPK during development. Weaver explores how proteostasis mechanisms maintain tissue integrity in aging, emphasizing metabolic signaling and lysosomal homeostasis.

His work integrates genetics, metabolomics, and advanced imaging to dissect cellular adaptation. Current NIH-funded projects target stress resilience pathways and their implications in regeneration.