Barbara Wirthl

Barbara Wirthl is a Researcher at the Institute for Computational Mechanics, Technical University of Munich (TUM), specializing in computational oncology and nanomedicine applications. She teaches advanced courses including Nonlinear Continuum Mechanics and Introduction to Current Research Topics in Computational Mechanics while conducting cutting-edge research on cancer therapy modeling.

Her educational background includes:

• PhD in Mechanical Engineering, Technical University of Munich (2018-2023)
• Master of Science in Mechanical Engineering, Technical University of Munich (2018)

Dr. Wirthl's research focuses on Computational Transport Oncophysics and Nanomedicine, with expertise in magnetic nanoparticle delivery systems, tumour growth modeling, and porous media mechanics. Her work integrates biomechanics with cancer immunotherapy, developing physics-based computational frameworks for optimizing nanoparticle-based treatments. She employs advanced techniques in sensitivity analysis and uncertainty quantification to address complex biological systems.

Analysis of her 2020-2025 publications reveals a strong trajectory toward integrating multiphase porous media models with clinical oncology applications. Her recent work emphasizes solver-independent computational frameworks (QUEENS), magnetic hyperthermia integration, and immune cell manipulation using nanoparticles. The research consistently bridges engineering mechanics with translational medicine, demonstrating increasing sophistication in modeling tumor microenvironments and treatment response.

Dr. Wirthl actively supervises graduate student research projects including Master's theses on computational angiogenesis modeling, term papers on interstitial fluid flow interactions, and MSE research internships on pharmacokinetics in tumor models. She has co-supervised multiple visualization and parameter study projects for tumor growth simulations with colleagues Jonas Nitzler and Johannes Kremheller.

She operates within the Laboratory for Numerical Mechanics (LNM) under Prof. Wolfgang A. Wall at TUM's Institute for Computational Mechanics, contributing to a multidisciplinary team focused on computational biomechanics applications in medical science. Her work leverages high-performance computing resources for complex tumor microenvironment simulations and nanoparticle transport modeling.