معرفی
Barbara Maier is a Principal Investigator at CeMM (Center for Molecular Medicine of the Austrian Academy of Sciences), specializing in tumor immunology and the tumor microenvironment (TME). Her research focuses on immune suppression mechanisms, antigen-presenting cell (APC) dynamics, and T cell exhaustion in cancer, aiming to enhance immunotherapy strategies like immune checkpoint blockade (ICB).
- Education: Studied molecular biology at the University of Vienna and earned a PhD from MedUni Vienna, investigating type I interferon in pulmonary inflammation under Professor Sylvia Knapp.
Barbara Maier’s work explores how tumor-associated APCs and myeloid cells shape T cell responses, using integrative approaches such as single-cell transcriptomics and high-throughput cell culture. Her research addresses critical questions about T cell dysfunction in the TME and draining lymph nodes, with the goal of developing next-generation immunotherapies targeting these pathways.
Her recent publications highlight studies on APC subsets in ICB response, spatial T cell exhaustion programs, and myeloid cell-based therapies. She leads the ERC Starting Grant 'REWIRE' (2024–2028) to manipulate lymph node niches for T cell reactivation and an FWF Stand-Alone Project (2024–2027) to enhance T cell immunity in tumor-draining lymph nodes.
