معرفی
Baohong Zhao, MD, PhD, is Professor of Biochemistry in Medicine at Weill Cornell Medical College (2024–present). She earned her DMD (2001) and BM (1999) from Peking University and her PhD from Showa University Graduate School, Japan (2008). Her research focuses on molecular mechanisms governing bone homeostasis, osteoclastogenesis, and inflammatory signaling in skeletal and immunological contexts.
Education
- Ph.D. — Showa University Graduate School (Japan), 2008
- D.M.D. — Peking University (China), 2001
- B.M. — Peking University Health Science Center (China), 1999
Research Interests
Professor Zhao’s laboratory integrates bone biology, immunology, and epigenetics to dissect how osteoclasts and osteoblasts communicate with immune cells. Key themes include:
- Long non-coding RNA Malat1 as a master regulator of bone repair and β-catenin signaling
- Transcription factor RBP-J in macrophage polarization and osteoclast differentiation
- TGFβ and TNF crosstalk driving inflammatory bone resorption
- MicroRNA networks controlling osteoclastogenesis and skeletal remodeling
- Adipoq-lineage progenitors as critical sources of M-CSF in bone marrow niches
Her work leverages conditional knockout mouse models, single-cell transcriptomics, and pharmacological inhibitors to translate findings into therapeutic targets for osteoporosis, Paget’s disease, and inflammatory arthritis.
Publications Overview
Since 2008, Professor Zhao has published >70 peer-reviewed articles, including high-impact studies in Nature Medicine, Nature Communications, Journal of Experimental Medicine, and Immunity. Recent work (2022-2025) highlights novel roles for lncRNAs, epigenetic regulators, and cytokine circuits in bone-immune interactions, collectively advancing understanding of skeletal diseases and identifying potential therapeutic avenues.
Scientific Awards & Honors
No specific awards are listed in the provided text.
Advising & Funding
No explicit information on current students or grant numbers is provided.
Laboratory & Teams
Professor Zhao leads an active research group at Weill Cornell Medical College, integrating molecular biology, immunology, and translational orthopedics to explore skeletal health and disease.
